Dissociation from the Oligomeric State Is the Rate-limiting Step in Fibril Formation by κ-Casein
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چکیده
منابع مشابه
Dissociation from the oligomeric state is the rate-limiting step in fibril formation by kappa-casein.
Amyloid fibrils are aggregated and precipitated forms of protein in which the protein exists in highly ordered, long, unbranching threadlike formations that are stable and resistant to degradation by proteases. Fibril formation is an ordered process that typically involves the unfolding of a protein to partially folded states that subsequently interact and aggregate through a nucleation-depende...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.m709928200